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Yi Cao

Mailing Address: Department of Physics, Nanjing University

22 Hankou Road, Gulou, Nanjing, Jiangsu, China PR, 210093

Email: caoyi@nju.edu.cn

Phone: 0086-25-8368-8960

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Academic Training 

¡¤         Ph.D., 2004-2009, Department of Chemistry, the University of British Columbia, Canada (Supervisor: Hongbin Li)

¡¤         M.Sc., 2001-2004, Department of Polymer Science and  Engineering, Nanjing University, China (Supervisor: Xiqun Jiang)

¡¤         B.Sc., 1997-2001, Department of Polymer Science and  Engineering, Nanjing University, China (Supervisor: Yiwu Quan and Qingmin Chen)

 

Academic Experience 

¡¤         Professor, 2010-date, Department of Physics, Nanjing University

¡¤         Postdoc, 2009-2010, Department of Chemistry, the University of British Columbia, Canada (Supervisor: Hongbin Li) 

 

Awards and Prizes 

¡¤         Program for New Century Excellent Talents in University £¨2011£©

¡¤         Arthur S Hawkes Scholarship in Chemistry from University of British Columbia (2008)

¡¤         Travel award for American Chemical Society 236th Annual Meeting (2008)

¡¤         Travel award for Biophysical Society 52nd Annual Meeting (2008)

¡¤         China Government Award for Outstanding Self-financed Students Abroad (2007)

¡¤         University of British Columbia Graduate Fellowship (2006-2007)

¡¤         Gladys Estella Laird Research Fellowship from University of British Columbia (2006-2007)

¡¤         Young Scientist Bursary from Gordon Research Conference on Protein Folding Dynamics (2006)

¡¤         Gladys Estella Laird Fellowship from University of British Columbia (2004-2006) 

  

Professional Societies 

¡¤         Member, American Biophysical Society (2006- )

¡¤         Member, American Chemical Society (2007-2010 )

  

Publications 

1.      ¡°How Do Proteins Unfold upon Adsorption on Nanoparticle Surfaces?¡± Pan, H, Qin, M, Meng, W, Cao, Y*, Wang, W* (2012) Langmuir. [Epub ahead of print]

2.      ¡°Photoinduced fibrils formation of chicken egg white lysozyme under native conditions.¡± Xie, JB, Cao, Y, Pan, H, Qin, M*, Yan, ZQ, Xiong, X, Wang, W*(2012) Proteins. doi: 10.1002/prot.24132. [Epub ahead of print]

3.      ¡°A versatile "multiple fishhooks" approach for the study of ligand-receptor interactions using single molecule atomic force microscopy.¡± Han, X, Qin, M, Pan, H, Cao, Y*, Wang, W* (2012) Langmuir  28:10020-5.

4.      ¡°Single-molecule experiments reveal the flexibility of a Per-ARNT-Sim domain and the kinetic partitioning in the unfolding pathway under force¡± Gao X, Qin, M, Yin, PG, Liang, JY, Wang, J, Cao, Y*, Wang, W* (2012) Biophysical Journal 102:2149-57.

5.      ¡°Low folding cooperativity of Hp35 revealed by single-molecule force spectroscopy and molecular dynamics simulation¡± Lv, CM, Tan, C, Qin, M., Zou, DW, Cao, Y*, Wang, W* (2012) Biophysical Journal 102:1944-51.

6.      ¡°A genetically encoded copper(I) sensor based on engineered structural distortion of EGFP.¡±

Liang, J, Qin, M, Xu, R, Gao, X, Shen, Y, Xu, Q, Cao, Y*, Wang, W* (2012) Chemical Communications 48:3890-2.

7.      ¡°Tandem modular protein-based hydrogels constructed using a novel two-component approach.¡±

Lv S, Cao, Y, Li, HB (2012) Langmuir 28:2269-74.

8.      ¡°Dynamics of protein folding and cofactor binding monitored by single molecule force spectroscopy¡± Cao, Y, Li, HB (2011) Biophysical 101:2009-17.

9.      ¡°Facile method of constructing polyproteins for single-molecule force spectroscopy studies.¡± Zheng, P, Cao, Y, Li, HB (2011) Langmuir 27:5713-5718.

10.  ¡°Mechanistic insight of photo-induced aggregation of chicken egg white lysozyme: the interplay between hydrophobic interactions and formation of intermolecular disulfide bonds.¡± Xie, J, Qin, M, Cao, Y, Wang, W (2011) Proteins 79: 2505-2516

11.  ¡°Formation of ¦Á-helix-based twisted ribbon-like fibrils from ionic-complementary peptides.¡± Zou, D, Cao, Y, Qin, M, Dai, W, Wang, W (2011) Chemical Communications 47: 7413-7415

12.  ¡°Single molecule force spectroscopy reveals that electrostatic interactions affect the mechanical stability of proteins.¡± Zheng, P, Cao, Y, Bu, T, Straus, SK, Li, HB Biophysical Journal 100:1534-1541

13.  ¡°Enhancing the mechanical stability of proteins through a cocktail approach¡± Cao, Y, Li, DY, Li HB (2011) Biophysical Journal 100: 1794-1799

14.  ¡°Single-molecule force-clamp spectroscopy: Dwell time analysis and practical considerations¡± Cao, Y, Li HB (2011) Langmuir 27: 1440-1447

15.  ¡°Protein mechanics: from single molecules to functional biomaterials¡± Li, HB, Cao, Y (2010) Accounts of Chemical Research 43: 1331-1341

16.  ¡°Designed biomaterials to mimic the mechanical properties of muscles¡± Lv, S, Dudek, DM, Cao, Y, Balamurali, MM, Gosline, J, Li, HB (2010) Nature 465: 69-73

17.  ¡°A force spectroscopy-based single-molecule metal binding assay¡± Cao, Y, Er, KS, Parhar, R, Li, HB (2009) Chemphyschem 10: 1450-1454

18.  ¡°Modulating the mechanical stability of extracellular matrix protein tenascin-C in a controlled and reversible fashion¡± Zhuang, SL, Peng, Q, Cao, Y, Li, HB (2009) Journal of Molecular Biology  390: 820-829

19.  ¡° Mechanical design of the third FnIII domain of tenascin-C¡± Peng, Q,; Zhuang, SL, Wang, MJ, Cao, Y, Li, HB (2009) Journal of Molecular Biology 386: 1327-1342  

20.  ¡°Nanomechanical properties of tenascin-X revealed by single-molecule force spectroscopy¡± Jollymore, A, Lethias, C, Peng, Q, Cao, Y, Li, HB (2009) Journal of Molecular Biology 385: 1277-1286  

21.   ¡°Single molecule force spectroscopy reveals engineered metal chelation is a general approach to enhance mechanical stability of proteins¡± Cao, Y, Yoo, T,  Li, HB (2008) Proceedings of the National Academy of Sciences USA 105: 11152-11157

22.  ¡°Engineering tandem modular protein based reversible hydrogels¡± Cao, Y, Li, HB (2008) Chemical Communications 35: 4144-4146

23.  ¡°Engineered elastomeric proteins with dual elasticity can be controlled by a molecular regulator¡± Cao, Y, Li, HB (2008) Nature Nanotechnology 3: 512-516

24.  ¡°Configuration entropy modulates the mechanical stability of protein GB1¡± Li, HB, Wang, HC, Cao, Y, Sharma, D, Wang, MJ (2008) Journal of Molecular Biology 379: 871-880

25.  ¡°Protein¨Cprotein interaction regulates proteins¡¯ mechanical stability¡± Cao, Y, Yoo, T, Zhuang SL, Li, HB (2008) Journal of Molecular Biology  378: 1132-1141

26.  ¡°Direct observation of Markovian behavior of the mechanical unfolding of individual proteins¡± Cao, Y, Kuske, R, Li, HB (2008) Biophysical Journal  95:782-788

27.  ¡°How do chemical denaturants affect the mechanical folding and unfolding of proteins?¡± Cao, Y, Li, HB (2008) Journal of Molecular Biology 375:316-324

28.  ¡°A functional single-molecule binding assay via force spectroscopy¡± Cao, Y, Balamurali, MM, Sharma, D, Li, HB (2007) Proceedings of the National Academy of Sciences USA 104:15677-15681

29.  ¡°Single-molecule force spectroscopy reveals a mechanically stable protein fold and the rational tuning of its mechanical stability¡± Sharma, D, Perisic, O, Peng, Q, Cao, Y, Lam, C, Lu, H and Li, HB (2007) Proceedings of the National Academy of Sciences USA 104: 9278-83

30.  ¡°Polyprotein of GB1 is an ideal artificial elastomeric protein¡± Cao, Y, Li, HB (2007) Nature Materials 6: 109-114

31.  ¡°Synthesis of alginic acid-poly[2-(diethylamino)ethyl methacrylate] monodispersed nanoparticles by a polymer-monomer pair reaction system¡± Guo, R, Zhang, LY, Jiang, Z, Cao, Y, Ding, Y, Jiang, XQ (2007) Biomacromolecules 8: 843-850

32.   ¡°Engineering proteins with novel mechanical properties by recombination of protein fragments¡± Sharma, D, Cao, Y, Li, HB (2006) Angewandte Chemie International Edition 45: 5633-5638

33.  ¡°Single molecule force spectroscopy reveals a weakly populated microstate of the FnIII domains of tenascin¡± Cao, Y, Li, HB (2006) Journal of Molecular Biology 361: 372-381

34.  ¡°The unfolding and folding dynamics of TNfnALL probed by single molecule force-ramp spectroscopy¡± Wang, MJ, Cao, Y, Li, HB (2006) Polymer 47: 2548-2554

35.  ¡°Nonmechanical protein can have significant mechanical stability¡± Cao, Y, Lam, C, Wang, MJ, Li, HB (2006) Angewandte Chemie International Edition 45: 642-645

36.  ¡°pH-induced self-assembly and capsules of sodium alginate¡± Cao, Y, Shen, XC, Chen, Y, Guo, J, Chen, Q, Jiang XQ (2005) Biomacromolecules 6: 2189-96

37.  ¡°Degradation behavior of poly(e-caprolactone)-b-poly(ethylene glycol)-b-poly(e-caprolactone) micelles in aqueous solution¡± Hu, Y, Zhang, LY, Cao, Y, Ge, H, Jiang, XQ, Yang, CZ (2004) Biomacromolecules 5: 1756-62

 

Conference Presentations/Posters/Abstracts 

1.      Cao, Y ¡°Single molecule AFM studies on protein folding and conformational dynamics¡± Fall Academic Meeting of Chinese Physical Society 2011, Hangzhou (Oral Presentation) (09/2011)

2.      Cao, Y, Qing, M, Wang W ¡°Protein mechanics: From single molecule to functional biomaterials¡± Fall Academic Meeting of Chinese Physical Society 2010, Tianjin (Oral Presentation) (09/2010)

3.      Cao, Y, Yoo, T, Li, HB ¡°A general approach to enhance mechanical stability of proteins¡± Frontiers in Biophysics: Forum 2009, Vancouver, BC (Oral Presentation) (01/2009)

4.      Cao, Y, Balamurali, MM, Sharma, D, Li, HB ¡°Functional single-molecule binding assay via force spectroscopy¡± 236th American Chemical Society Meeting, Philadelphia, PA (Poster Presentations) (08/2008)

5.      Cao, Y, Balamurali, MM, Sharma, D, Li, HB ¡°A functional single-molecule binding assay via force spectroscopy¡± International Scanning Probe Microscopy Conference, Seattle, WA (Oral Presentation) (06/2008)

6.      Cao, Y, Li, HB ¡°How do chemical denaturants affect the mechanical folding and unfolding of proteins?¡± 52nd Biophysical Society Meeting, Long beach, CA (Oral Presentation) (03/2008)

7.      Cao, Y, Li, HB ¡°Polyprotein of GB1 is an idea artificial elastomeric protein¡± Single Molecule Mechanics Workshop, Toronto, ON (Oral Presentation) (04/2007)

8.      Cao, Y, Li, HB ¡°Towards engineering artificial molecular springs-polyprotein of GB1 is an idea elastomeric protein¡±  51st Biophysical Society Meeting, Baltimore, MA (Abstract) (03/2007)

9.      Cao, Y, Li, HB ¡°Towards engineering artificial molecular springs¡± Biophysical retreat, Vancouver, BC (Oral Presentation) (10/2006)

10.  Cao, Y, Lam, C, Wang, MJ, Li, HB ¡°Mechanical unfolding of non-mechanical protein GB1¡± Gordon Research Conference on Protein Folding Dynamics, Ventura, CA (Poster Presentation) (01/2006)

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